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Randomized double-blind placebo-controlled crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects
Joe A Vinson1, email@example.com, Bryan Burnham2, Mysore V Nagendran3. (1) Chemistry, University of Scranton, Scranton, PA 18510, United States, (2) Psychology, University of Scranton, Scranton, PA 18510, United States, (3) Health Sciences Clinic, Bangladore, India
Obesity is a growing epidemic in industrialized societies. Overweight and obese subjects in the US are now 68% of the population. There are prescription drugs for weight loss but efficacy is low and side effects cause a large dropout rate in clinical studies. We have investigated an extract of green (unroasted) coffee beans high in coffee polyphenols. A 22-week cross-over study was conducted in 16 sub-obese adults to examine the efficacy and safety of a commercial product GCAÔ. Subjects receive a high-dose (1050 mg), low-dose (700 mg), and placebo in separate six-week treatment periods followed by two-week washouts. Primary measurements were body weight, body mass index (BMI) and fat mass (BIA). Heart rate and blood pressure were measured. There was a significant decrease (improvement) in all parameters except blood pressure. Weight loss averaged 8 kg withot side effects. This product is a safe, effective, and inexpensive nutraceutical for weight loss.