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Vitamin C May Lower Gout Risk in Men

On : 24 April, 2013

In : Gout


A report in the Archives of Internal Medicine indicates that vitamin C intake of at least 1500 milligrams per day reduces the odds of gout by 45 percent compared with an intake of less than 250 milligrams per day.

Vitamin C Intake and the Risk of Gout in Men

Hyon K. et al.

Arch Intern Med. 2009; 169(5):502-507.

Background Several metabolic studies and a recent double-blind,placebo-controlled, randomized trial have shown that highervitamin C intake significantly reduces serum uric acid levels.Yet the relation with risk of gout is unknown.

Methods We prospectively examined, from1986 through 2006,the relation between vitamin C intake and risk of incident goutin 46 994 male participants with no history of gout atbaseline. We used a supplementary questionnaire to ascertainthe American College of Rheumatology criteria for gout. VitaminC intake was assessed every 4 years through validated questionnaires.

Results During the 20 years of follow-up, we documented1317 confirmed incident cases of gout. Compared with men withvitamin C intake less than 250 mg/d, the multivariate relativerisk (RR) of gout was 0.83 (95% confidence interval [CI], 0.71-0.97)for total vitamin C intake of 500 to 999 mg/d, 0.66 (0.52-0.86)for 1000 to 1499 mg/d, and 0.55 (0.38-0.80) for 1500 mg/d orgreater (P < .001 for trend). The multivariateRR per 500-mg increase in total daily vitamin C intake was 0.83(95% CI, 0.77-0.90). Compared with men who did not use supplementalvitamin C, the multivariate RR of gout was 0.66 (95% CI, 0.49-0.88)for supplemental vitamin C intake of 1000 to 1499 mg/d and 0.55(0.36-0.86) for 1500 mg/d or greater (P < .001for trend). Conclusions Higher vitamin C intake is independently associatedwith a lower risk of gout. Supplemental vitamin C intake maybe beneficial in the prevention of gout.


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