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Synthetic food coloring and behavior: A dose response effect in a double-blind, placebo-controlled, repeated measures study
Rowe K and Rowe K.
J. Pediatrics 125: 691-698, 1994.
“This study demonstrated a functional relation between the ingestion of a synthetic food color (tartrazine) and behavioral change in 24 atopic (allergic) children, with marked reactions being observed at all six dosage levels of dye challenge. When they reacted to the (food) dye, the younger children had constant crying, tantrums, irritability, restlessness, severe sleep disturbance, and were described as ‘out-of-control, easily distracted and excited, and high as a kite’.”