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In double-blind, head-to-head comparison study, investigators compared 200 mg of oral L-theanine with 1 mf alpazolam (XanaxÒ), an anti-anxiety drug that is usually taken in only .25 to .50 mg doses. Results: theanine, but not alprazolem or the placebo, induced relaxing effects that were evident at the initial measurement of whether a person felt tranquil versus troubled.
Lu K, Gray MA, et al. The acute effects of L-theanine in comparison with alprozolam on anticipatory anxiety in humans. Hum Psychopharmacol. 2004Oct;19(7):457-65
The result of this study are remarkable. Theanine, but not alprazolam (Xanax) or the placebo, induced relaxing effects that were evident at the initial measurement of whether a person felt tranquil versus troubled. This study is even more impressive when the dose of alprazolam is taken into consideration. One milligram is a substantial dose of this medication – generally, most people use just 0.25 to 0.5 mg of alprazolam. Theanine’s superior performance to a potentially habit-forming medication is fabulous.