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Dr. Gaila Mackenzie-Strawn
CFMP, DNM, MS, DC ,CTN
On : 29 November, 2012
In : Headaches
Cephalalgia. 2010 Jan;30(1):68-76.
Baad-Hansen L, Cairns B, Ernberg M, Svensson P.
Department of Clinical Oral Physiology, School of Dentistry, University of Aarhus, Aarhus, Denmark. email@example.com
We conducted a double-blinded, placebo-controlled, crossover study to investigate the occurrence of adverse effects such as headache as well as pain and mechanical sensitivity in pericranial muscles after oral administration of monosodium glutamate (MSG). In three sessions, 14 healthy men drank sugar-free soda that contained either MSG (75 or 150 mg/kg) or NaCl (24 mg/kg, placebo). Plasma glutamate level, pain, pressure pain thresholds and tolerance levels, blood pressure (BP), heart rate and reported adverse effects were assessed for 2 h. No muscle pain or robust changes in mechanical sensitivity were detected, but there was a significant increase in reports of headache and subjectively reported pericranial muscle tenderness after MSG. Systolic BP was elevated in the high MSG session compared with low MSG and placebo. These findings add new information to the concept of MSG headache and craniofacial pain sensitivity.
[PubMed – indexed for MEDLINE]