Metabolomix Complete Nutritional Assessment
Metabolomix+ : A Non-Invasive Personalized Assessment
The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. A first morning void (FMV) urine collection, with optional add-on bloodspot finger stick and buccal swab, the Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids. Insights gained from the Metabolomix+ nutritional test allows clinicians to target nutritional therapies to the precise needs of their patients.
Additional markers are availablefor an even greater overview of a patient’s nutritional status with easy to add modules based on a patient’s unique needs.
What is a functional nutritional assessment?
Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.
Enzymes that are responsible for metabolizing organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels.1-5Recommendations for nutrient supplementation based on elevated organic acid results are generated using a literature-based proprietary algorithm.
Traditionally, urinary organic acid assessment has been used in neonatal/pediatric medicine to identify genetic inborn errors of metabolism, with severity depending on the degree and type of error.* In many cases of genetic inborn errors, the enzymatic defect may be compensated for by high doses of specific vitamin and mineral cofactors and/or dietary interventions. Intervention with higher-dose nutrient cofactors may also be effective in cases of decreased enzyme activity due to causes other than frank inborn errors.
* Genova’s organic acid testing is not intended for the diagnosis of neonatal inborn errors of metabolism.
Which patients might benefit from functional nutritional testing?
Common clinical indications for testing include:
- Mood Disorders
- Mitochondrial Dysfunction
- Fatigue
- Chronic Stress
- Inflammation
Several diseases are associated with abnormal organic acid, amino acid, and fatty acid levels such as depression, anxiety, cardiovascular disease, neurocognitive decline, diabetes, cancer, anorexia, and many others.
About the Metabolomix+ Profile
The Metabolomix+ Profile report allows for easy interpretation and clinically actionable results. It includes a Suggested Supplement Schedule that provides personalized recommendations based on test results. The Interpretation-At-A-Glance section of the report provides facts related to nutrient function, causes and complications of their deficiencies, and dietary sources.
The Metabolomix+ Profile report categorizes results into several metabolic areas:
COMPONENTS
Organic Acids
- Malabsorption and Dysbiosis
- Cellular Energy and Mitochondrial Metabolites
- Neurotransmitter Metabolites
- Vitamin Markers
- Toxin and Detoxification Markers
- Tyrosine Metabolism
Amino Acids
- Nutritionally Essential Amino Acids
- Nonessential Protein Amino Acids
- Intermediary Metabolites
- Dietary Peptide Related Markers
Oxidative Stress Markers
+COMPONENTS
Essential and Metabolic Fatty Acids – Bloodspot(if selected as add-on profile)
- Omega 3 Fatty Acids
- Omega 6 Fatty Acids
- Omega 9 Fatty Acids
- Saturated Fatty Acids
- Monounsaturated Fatty Acids
- Delta-6 Desaturase Activity
- Cardiovascular Risk
Nutrient and Toxic Elements(if selected as add-on profile)
Genomics(if one or more of the following SNPs are selected as add-ons)
- APO E (C112R + R158C)
- MTHFR Combined (A1298C + C677T)
- TNF-α
- COMT (V158M)
Genova’s Methodology
Urinary organic and amino acids are measured via GCMS, LC/MS/MS and alkaline picrate. Fatty acids are measured via GCMS. Urinary oxidative stress markers are measured using colorimetric, thiobarbituric acid reactive substances (TBARS) and LC/MS/MS. Nutrient and toxic elements are measured using ICP-MS and Kinetic (Jaffe). Reference ranges are age and gender specific and are based on a questionnaire-qualified healthy cohort. Testing is not performed in patients under 2 years old.
